EBOO/EBO2 Therapy in Sioux Falls
Extracorporeal blood oxygenation and ozonation is one of the most advanced integrative therapies available today. A portion of your blood is gently filtered, enriched with medical-grade ozone and oxygen, and returned to your body. It is now available at Divinity Wellness, and it is the most significant new offering in our clinic's history.

What is EBOO/EBO2?
EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. EBO2 refers to the enhanced protocol our clinic follows. A small amount of your blood is drawn through a specialized filter, enriched with medical-grade ozone and pure oxygen, and returned to your bloodstream. The entire process is performed under clinical supervision. Traditional ozone therapies work on a small volume of blood at a time; EBOO/EBO2 processes considerably more and combines ozonation with filtration. Patients living with chronic inflammation, autoimmune conditions, persistent infection, or the long recovery that follows cancer treatment often explore EBOO/EBO2 as part of an integrative approach.
What patients come to us for
- Autoimmune conditions
- Chronic fatigue and post-viral fatigue including long COVID
- Lyme disease and other persistent infections
- Integrative support during and after cancer treatment
- Chronic inflammatory conditions
What to expect
- 01Consultation and clinical review - your physician reviews your history, symptoms, and any relevant test results to confirm the therapy is appropriate.
- 02Preparation and connection - you are made comfortable in our treatment room and connected to the EBOO/EBO2 system through a small IV line.
- 03Filtration and ozonation - your blood passes through the filtration and ozonation circuit at a steady, monitored rate, typically sixty to ninety minutes.
- 04Follow-up and next steps - we monitor you briefly, offer water and light nourishment, and go through what to expect over the coming days.
